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2002•Northwest Pharmaceutical JournalRequires access

Studies on release rates and bioavailability of diclofenac sodium sustained release capsules in rabbits

Ding Guang-lin

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Abstract

Objective Diclofenac sodium sustained release capsules(DS-SRC) were prepared. The release rate and bioavailability of DS-SRC were studied. MethodTo study release mechanism by determining dissolution rate and study relative bioavailability of DS-SRC by determining serum diclofenac sodium concentrations in rabbits. Results The release profile of DS-SRC followed Higuchi kinetics. This kind of sustained release preparation has some outstanding characteristics compare with generic tablets, such as release stability and high bioavailability. Conclusion DS-SRC showed an obvious sustained release effect.

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What this paper is about

Objective Diclofenac sodium sustained release capsules(DS-SRC) were prepared. The release rate and bioavailability of DS-SRC were studied. MethodTo study release mechanism by determining dissolution rate and study relative bioavailability of DS-SRC by determining serum diclofenac sodium concentrations in rabbits. Results The release profile of DS-SRC followed Higuchi kinetics. This kind of sustained release preparation has some outstanding characteristics compare with generic tablets, such as release stability and high bioavailability. Conclusion DS-SRC showed an obvious sustained release effect.

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Available abstract

Objective Diclofenac sodium sustained release capsules(DS-SRC) were prepared. The release rate and bioavailability of DS-SRC were studied. MethodTo study release mechanism by determining dissolution rate and study relative bioavailability of DS-SRC by determining serum diclofenac sodium concentrations in rabbits. Results The release profile of DS-SRC followed Higuchi kinetics. This kind of sustained release preparation has some outstanding characteristics compare with generic tablets, such as release stability and high bioavailability. Conclusion DS-SRC showed an obvious sustained release effect.

Key concepts: Bioavailability, Diclofenac Sodium, Chemistry, Pharmacology, Chromatography, Dissolution, Kinetics, Medicine

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