Effects of the PEMFs with different intensity on osteoporosis in rats

AIM:To study the effects of pulsed electromagnetic fields (PEMFs) with different intensity on osteoporosis in ovariectomized rats. METHODS: Thirty female SD rats were randomly divided into 3 groups (n=10 in each group), and the osteoportic models were established by performing bilateral ovariectomized. The rats in magnetic groups were fed in 15 Hz PEMFs, in which pulse duration was set to be 5 ms (6 h/d). The magnetic intensities were adjusted to 4×10-4 T and 15×10-4 T respectively. The rats in control group were just fed in coils, and the instrument of PEMFs was powered off. After 12 weeks, the changes of serum bone carboxyglutamic acid containing prorein (BGP), bone mineral density (BMD) and biomechanical properties were examined. RESULTS: Compared with control group, the values in magnetic groups such as BMD, maximum load and structural rigidity, increased significantly (P0.05). However, the values of serum BGP decreased obviously (P0.05). In addition, statistical significance was detected in these values between the two magnetic groups (P0.05). CONCLUSION: PEMFs is helpful to the treatment and prevention of osteoporosis, and the parameters can influence the curative effects.