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Anticoagulant and Fibrinolytic Activities of Polysaccharides from Curcuma kwangsiensis

Tang Lu

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Abstract

Objective To study anticoagulant and fibrinolytic activities of polysaccharides from Curcuma kwangsiensis.Methods The mice were administered by gavage with low,medium and high concentrations of polysaccharides for 3 days.Clotting time(CT),prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT) and fibrinogen(Fbg) of mice were detected.Fibrin plate method was performed to determine the fibrinolytic activiy of medicated serum in vitro.Results The CT,APTT and TT were prolonged significantly(P0.05),but the PT and Fbg did not change.Conclusion The polysaccharides from Curcuma kwangsiensis have anticoagulant activities and exert their anticoagulant activities through intrinsic pathway and common pathway of coagulation.

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What this paper is about

Objective To study anticoagulant and fibrinolytic activities of polysaccharides from Curcuma kwangsiensis.Methods The mice were administered by gavage with low,medium and high concentrations of polysaccharides for 3 days.Clotting time(CT),prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT) and fibrinogen(Fbg) of mice were detected.Fibrin plate method was performed to determine the fibrinolytic activiy of medicated serum in vitro.Results The CT,APTT and TT were prolonged significantly(P0.05),but the PT and Fbg did not change.Conclusion The polysaccharides from Curcuma kwangsiensis have anticoagulant activities and exert their anticoagulant activities through intrinsic pathway and common pathway of coagulation.

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Available abstract

Objective To study anticoagulant and fibrinolytic activities of polysaccharides from Curcuma kwangsiensis.Methods The mice were administered by gavage with low,medium and high concentrations of polysaccharides for 3 days.Clotting time(CT),prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT) and fibrinogen(Fbg) of mice were detected.Fibrin plate method was performed to determine the fibrinolytic activiy of medicated serum in vitro.Results The CT,APTT and TT were prolonged significantly(P0.05),but the PT and Fbg did not change.Conclusion The polysaccharides from Curcuma kwangsiensis have anticoagulant activities and exert their anticoagulant activities through intrinsic pathway and common pathway of coagulation.

Key concepts: Partial thromboplastin time, Thrombin time, Prothrombin time, Polysaccharide, Clotting time, Fibrin, Fibrinogen, Anticoagulant

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Anticoagulant and Fibrinolytic Activities of Polysaccharides from Curcuma kwangsiensis — Research Paper | ScholarLens