Clinical Significance of Cerebrospinal Fluid Adenosine Deaminase of Children with Tuberculous Meningitis

Objective: Evaluation of tuberculous meningitis with cerebrospinal fluid of adenosine deaminase(CSF-ADA) activity to clinical diagnosis significance and effect of value judgment. Method: To choose 122 cases hospitalized children as the research object, 56 cases of tuberculous meningitis was the case group (group A). 66 cases of meningitis of n/med tuberculosis sex as control group, including bacterial meningitis 32 cases (group B), and viral meningitis 34 cases (C group), using enzyme coupling Trinder spectrometry to analyze CSF-ADA activity before treatment. 56 cases of tuberculous meningitis in antitubercular treatment children after 2 weeks and six weeks respectively detection CSF-ADA. Result: The CSF-ADA activity of group A was(11.8±4.4) U/L, compared with group B(6.1±2.8) U/L, group C(4.9±3.1) U/L, there was a significant difference meaning (F=45.150, P=0.000). Taking the CSF-ADA≥8 U/L as critical value in identification of tuberculous meningitis had the highest value, and sensitivity was 87.72% and specificity was 90.77%. As patients improved, CSF-ADA activity gradually reduced. Conclusion: CSF-ADA activity was 8 U/L can be used as a auxiliary diagnosis index of tuberculous meningitis, CSF-ADA activity can be used as curative effect judgment reference index.