The relationship of pathologic characteristics and clinical manifestations in children with Henoch-Schonlein Purpura Nephritis(HSPN)

Objective To study the relationship between pathologic characteristics and clinical manifestations as well as immunity complex deposits in children with Henoch Schonlein purpura nephritis(HSPN).Methods Analyze clinic diagnosis,pathologic patterns,immunity complex deposits in 74 children of HSPN.Results Clinical features: mild features occupied 86.5%,nephrotic syndrome features occupied 12.2%,chronic nephritis occupied 1.3%: Ⅱ grade and Ⅲ grade was the main kind of pathology change of renal tissues,the rate was 44.6% and 48.6%.Clinical classification and pathologic type for comparison shows: Pure hematuria pathology classification for Ⅱ grade occupied 75%,Ⅲ grade occupied 16.7%;Pure proteinuria pathology classification of Ⅱ grade occupid 33.3%,Ⅲ accounted 66.7%;Hematuria+proteinuria for Ⅱ grade occupied 40.8% and Ⅲ grade occupied 55.1%.Nephrotic syndrome type level Ⅱ,Ⅲ was 33.3%,55.6% respectively.Protein urine to children with mild level of positive appear proteinuria accounted for 67.7% of children.Moderate proteinuria accounted for 17.7%,a large number of proteinuria accounted for 14.5%.IgA+IgM+C3 and IgA+IgG+IgM+C3 immunity complex deposits was the most common type,the rate was 40.5% and 25.7%.Its corresponding pathological types on the main performance for Ⅱ and Ⅲ grade.Conclusion Purpura nephritis clinical type mainly to light,Ⅱ grade and Ⅲ grade was main kind of pathology change of renal tissues.Children of the urinary protein with proteinuria increase,pathological types have increased tendency.It is explained that purpura nephritis clinical points of the seriousness of this type and pathological changes are closely linked.But there are no consistency,light clinical classification of children especially simple hematuria type,kidney pathological appeared different degree of change,therefore,it is necessary to do wear the kidney check in pure hematuria type.