Effect of dexmedetomidine on oxidative stress of patients with laparoscopic hysterectomy

Objective To observe and evaluate the effect of dexmedetomidine( Dex) on oxidative stress of patients with laparoscopic hysterectomy. Methods Forty patients with laparoscopichysterectomy were assigned into 2 groups randomly: D group( Dex,n = 20),dexmedetomidine infusion intravenous loading dose of 1 μg·kg- 1( infusion completed within 15 minutes),then 0. 5 μg·kg- 1· h- 1continuous infusion to 30 min before the end of surgery; C group( The control group,n = 20),infusion of saline in the same way. Records mean arterial pressure( MAP) and heart rate( HR) and venous blood sample was taken at four time points: before anesthesia( T0),immediate end of pneumoperitoneum( T1),30 min after pneumoperitoneum( T2) and 24 h( T3). Concentrations of hydrogen peroxide( H2O2),malondialdehyde( MDA) and total antioxidant status( TAS) in plasma were determined. Results Compared with T0,Group C MAP at T1、T2 time difference was significant( P 0. 05). Compared with T0,H2O2,MDA increased and TAS reduced in the two groups at T1,T2( P 0. 05). There was no significant difference between T0 and T3in group D in H2O2,MDA( P 0. 05),while H2O2,MDA were still higher in group C( P 0. 05). Compared with group C,group D had low MDA concentration and high TAS concentration at T2,T3 time points( P 0. 05). There were no significant differences in H2O2 and MDA at T2 between the two groups( P 0. 05). However,group D,compared with group C,had a higher TAS concentration( P 0. 05). Conclusion Dexmedetomidine can reduce oxidative stress of patients undergoing laparoscopic hysterectomy.