Transcatheter Hepatic Arterial Perfusion of Cytokine-induced Killer Cells Combined with Ultra-fluid Lipiodol Embolization in Treatment of Hepatocellular Carcinoma

Objective To discuss the clinical significance of transcatheter hepatic arterial perfusion of cytokine-induced killer(CIK) cells combined with ultra-fluid lipiodol embolization in treatment of hepatocellular carcinoma(HCC).Methods Using the Seldinger's method,38 patients with HCC were treated by transcatheter hepatic arterial perfusion of CIK cells combined with ultra-fluid lipiodol(UFL)embolization(study group) and 62 patients with HCC were treated by transcather hepatic arterial chemoembolization(TACE) and percutaneous ethanol injection(PEI)(double interventional treatment group).Results There were significant differences in CD3,CD4 and CD8 between two groups before and after the treatment(P0.05).The decreased ratio of the serum AFP,in 0.5,1 and 2 year survival ratio were significantly different between two groups(P0.05),but there was no difference between two groups in short-term therapy effective(P0.95).Conclusion By transcatheter hepatic arterial perfusion of CIK cells combined with UFL embolization in treatment of HCC can prolong the survival period of the patients.