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2010•Clinical Medicine & EngineeringRequires access

The Monitor Application of Serum Cystatin C in Chronic Kidney Disease

Yingwei Yang

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Abstract

Objective To explore the meaning of monitoring serum Cystatin C in chronic kidney disease. Methods The levels of serum Cystatin C and the amounts of creatinine(Scr) in 75 patients with chronic kidney disease were determined by particle immunonephrology method and enzymeassay. Glomerular filtration rate(GFR) was estimated by the plasma clearance of 99mTc-DTPA. Then compare their dependencies,evaluate the sensitivity and specificity for the diagnosis of chronic kidney disease with GFR reduced. Results The correlation coefficients with 99mTc-DTPA were-0.681 for serum Cystatin C,-0.595 for serum creatinine(all P 0.001) . Compare the sensitivity and specificity with Cystatin C and Scr,the former was better than the latter. Conclusion Serum Cystatin C is a more sensitive and specific maker for GFR.

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What this paper is about

Objective To explore the meaning of monitoring serum Cystatin C in chronic kidney disease. Methods The levels of serum Cystatin C and the amounts of creatinine(Scr) in 75 patients with chronic kidney disease were determined by particle immunonephrology method and enzymeassay. Glomerular filtration rate(GFR) was estimated by the plasma clearance of 99mTc-DTPA. Then compare their dependencies,evaluate the sensitivity and specificity for the diagnosis of chronic kidney disease with GFR reduced. Results The correlation coefficients with 99mTc-DTPA were-0.681 for serum Cystatin C,-0.595 for serum creatinine(all P 0.001) . Compare the sensitivity and specificity with Cystatin C and Scr,the former was better than the latter. Conclusion Serum Cystatin C is a more sensitive and specific maker for GFR.

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Available abstract

Objective To explore the meaning of monitoring serum Cystatin C in chronic kidney disease. Methods The levels of serum Cystatin C and the amounts of creatinine(Scr) in 75 patients with chronic kidney disease were determined by particle immunonephrology method and enzymeassay. Glomerular filtration rate(GFR) was estimated by the plasma clearance of 99mTc-DTPA. Then compare their dependencies,evaluate the sensitivity and specificity for the diagnosis of chronic kidney disease with GFR reduced. Results The correlation coefficients with 99mTc-DTPA were-0.681 for serum Cystatin C,-0.595 for serum creatinine(all P 0.001) . Compare the sensitivity and specificity with Cystatin C and Scr,the former was better than the latter. Conclusion Serum Cystatin C is a more sensitive and specific maker for GFR.

Key concepts: Cystatin C, Medicine, Renal function, Creatinine, Kidney disease, Cystatin, Plasma clearance, Internal medicine

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