2013•Journal of Beijing University of Traditional Chinese MedicineRequires access
Regulative effects of music electroacupuncture on expressions of hippocampus monoamine neurotransmitters in rats with chronic stress depression
Zhigang Li
Open publisher page 2 citations
Abstract
Objective To observe the influences of music electroacupuncture on hippocampus monoamine neurotransmitters,5-hydroxytryptamine(5-HT),dopamine(DA) and norepinephrine(NE),in rats with chronic stress depression.Methods SD rats were randomly divided into blank group,model group,flouxetine group and music electroacupuncture group.The rat model of chronic stress depression was established by applying chronic stress combining separation in all groups except blank group.The behavior changes of rats were reviewed through open-field test,sucrose consumption detection and body weight measure.The expressions of 5-HT,DA and NE were detected by using radioimmunoassay.Results Compared with blank group,number of horizontally crossed grids,standing times,sucrose consumption and body weight decreased significantly in model group(P0.01).Compared with model group,number of horizontally crossed grids,standing times,sucrose consumption and body weight increased significantly in flouxetine group and music electroacupuncture group(P0.05).Compared with blank group,the content of 5-HT,DA and NE decreased significantly in model group(P0.01).Compared with model group,the content of 5-HT,DA and NE increased in flouxetine group(P0.05),and increased in music electroacupuncture group(P0.01,P0.05).Compared with flouxetine group,the content of 5-HT increased in music electroacupuncture group(P0.05).Conclusion Music electroacupuncture can relieve the ethologic symptoms in rats with chronic stress depression,so it has anti-depression effect.Music electroacupuncture can improve the levels of 5-HT,DA and NE,which may be one of its anti-depression mechanisms.