2012•Shiyong yixue zazhiRequires access
Expressions and significances of HGF and c-Met in the malignant transformation of nasal inverted papilloma
Qiao Guo-yon
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Abstract
Objective To analysis the expressions of HGF and c-Met in different stages of intranasal inverted papilloma and try to explore the effects of HGF and c-Met in the malignant transformation of nasal inverted papilloma.Methods 30 cases with confirmed malignant papilloma and 55 cases with nasal inverted papilloma in our hospital from Jan 2005 to Dec 2010 were received as experimental objects.All the patients underwent endoscopic removal of diseased tissue.The expressions of HGF and c-Met in nasal inverted papilloma tissue,adjacent tissues and malignant tissues were determined by immunohistochemical method,and the stain score of each sample was calculated.The expressions of HGF and c-Met in different stages of nasal inverted papilloma were analyzed.Results The staining scores of HGF and c-Met in malignant tissue were higher than those in nasal inverted papilloma tissues and the adjacent tissues,the expressions of HGF and c-Met in the adjacent tissues were the minimum.Expressions of HGF and c-Met in T1 stage of inverted papilloma were significantly lower than those in T3 stage(P 0.05,P 0.01) and T4 stage(both P 0.01).Conclusions The expressions of HGF and c-Met in nasal inverted papilloma were related to its stage,and may contribute to the malignant transformation of it.