EVALUATION OF REGIONAL DIASTOLIC FUNCTION IN DOGS WITH ACUTE MYOCARDIAL INFARCTION BY TISSUE INTENSITY CURVE

Objective:To detect the tissue intensity features of regional wall abnormalities in dogs with acute myocardial infarction during diastolic period,and the results from this study provide experimental foundation for tissue intensity cure(TIC) in estimating the regional left ventricular diastolic function of acute myocardial infarction.Methods:Twelve dogs ligated left anterior descending coronary artery(LADCA) were performed at apical two-chamber view by doppler tissue imaging in pre-ligation and post-ligation 4 hours.Tissue intensity of LV segments was analyzed by tissue intensity curves synchronously.Results:Pre-ligation TIC showed increasing negative value from base to apex during the whole relaxation period;in post-ligation 4 hours,this law disappeared and the negative value of dB in infarction segments was bigger than that of pre-ligation.During ventricular filling phase post-ligation the value of dB of infarction segment was bigger than pre-ligation and non-infarction segment(P0.01).Conclusion:The dB value of myocardial tissue increases during acute myocardial infarction(AMI).The infarction and normal myocardium can be distinguished and assessed by quantitatively analyzing the change of tissue intensity.And TIC is very useful for clinical diagnosing acute myocardial infarction and positioning the segment of infarction.