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2005•Chinese Journal of Hospital PharmacyRequires access

Study on the immune mechanism of anti-tumor by lycium barbarum polysaccharides

Fan Xiu Zhu

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Abstract

OBJECTIVE To explore the immune effects of lycium barbarum polysaccharides (LBP) on the t umor mice.METHODS 60 mice were grouping to six groups.After treated with different dosage of LBP, the weight of thymus gland,the antibody and active of CTL were detected.RESULTS LBP could dose-dependently inhibit tumor.The best curing dose of LBP was 10 mg ·kg -1·d -1.And it also increased the secretion of antib ody and enhanced the active of CTL.CONCLUSION The mechanism of tumor-inhibition by LBP could be due to enhance the immunity of the mice,both from the cellular immunity and body fluid immunity.

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What this paper is about

OBJECTIVE To explore the immune effects of lycium barbarum polysaccharides (LBP) on the t umor mice.METHODS 60 mice were grouping to six groups.After treated with different dosage of LBP, the weight of thymus gland,the antibody and active of CTL were detected.RESULTS LBP could dose-dependently inhibit tumor.The best curing dose of LBP was 10 mg ·kg -1·d -1.And it also increased the secretion of antib ody and enhanced the active of CTL.CONCLUSION The mechanism of tumor-inhibition by LBP could be due to enhance the immunity of the mice,both from the cellular immunity and body fluid immunity.

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Available abstract

OBJECTIVE To explore the immune effects of lycium barbarum polysaccharides (LBP) on the t umor mice.METHODS 60 mice were grouping to six groups.After treated with different dosage of LBP, the weight of thymus gland,the antibody and active of CTL were detected.RESULTS LBP could dose-dependently inhibit tumor.The best curing dose of LBP was 10 mg ·kg -1·d -1.And it also increased the secretion of antib ody and enhanced the active of CTL.CONCLUSION The mechanism of tumor-inhibition by LBP could be due to enhance the immunity of the mice,both from the cellular immunity and body fluid immunity.

Key concepts: Lycium, CTL*, Immune system, Polysaccharide, Immunity, Secretion, Antibody, Cellular immunity

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