Effects of Dexmedetomidine on Sevoflurane Consumption in Patients Undergoing Laparoscopic Surgery

Objective To investigate the effects of two doses of dexmedetomidine(Dex) on sevoflurane concentration with remifentanil and hemodynamics during gynecological laparoscopic surgery.Methods Ninety patients during laparoscopic surgery who received general anesthesia were randomly divided into three groups:group C received a saline infusion after anesthesia induction,group L received Dex 0.4μg/kg and group H received Dex 0.8μg/kg.The sevoflurane concentration was adjusted to maintain BIS within 45-55.HR,SBP,DBP and sevoflurane concentration were continuously monitored.SBP,DBP and HR were recorded before the infusion of dexmedetomidine(T0),10 minutes after the infusion of Dex(Tl),after the pneumoperitoneum(T2),30 minutes after the pneumoperitoneum(T3),and at the time of de-pneumoperitoneum(T4).Recovery time and adverse reactions were also recorded.Results The sevoflurane concentrations of group L and group H were lower than that of group C(P0.05),and the sevoflurane concentration of group H was lower than that of group L(P0.05).Compared with group C,HR,SBP and DBP were significantly decreased at T2,T3 and T4 in groups L and H.There was no significant difference between group L and H in waking time and adverse effects(P0.05).Conclusion Adjunctive use of Dex 0.4 and 0.8μg/kg could decrease the sevoflurane concentration,maintain hemodynamic stability during gynecological laparoscopic surgery,and has no severe adverse effects on waking time.