Controlled-Released Dinoprostone for Induction of Term Pregnancy

Objective: To explore the efficacy and safety of controlledreleased dinoprostone used for induction of term pregnancy.Methods:One hundred and twenty pregnant women of singleton pregnancy,cephalic presentation,reason for induction.Bishop score6 points were divided into 3 groups at random,the dinoprostone,misoprostol and oxytocin groups,each group had 40 pregnant women.The cervical maturity(by Bishop scoring),the time to labor starting,condition of delivery,fetal and neonatal condition were compared among the 3 groups after inserting the suppository.Results:Bishop score was 7.6±1.5 for 12 h in the dinoprostone group,which was significantly higher than 5.8±1.4 in the misoprostol group and 4.2±1.1 in the oxytocin group,(P0.01).Total efficiency was 95% for 24 h in the dinoprostone group,which was significantly higher than 67.5% and 32.5% in the misoprostol and oxytocin group,(P0.01).The time to delivery was 18.3±6.4 in the dinoprostone group after inserting the suppository,which was significantly lower than 27.8±7.6 and 34.5±10.3 in the misoprostol and oxytocin group,(P0.01).The rate of vagina delivery was 70% in dinoprostone group,higher than Misoprostol group 52.5% and oxytocin group 40%,P0.05.while there was no difference in time of labor,postpartum hemorrhage,fetal and neonatal conditions among the 3 groups.Conclusion:Controlled-released dinoprostone is a safe and efficient medicine used for induction of term pregnancy.