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2002•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access

Effect of l-menthol on mucosa absorption of ciprofloxacin

Zhao Huai

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Abstract

AIM: To investigate the effect of l menthol on the absorption of ciprofloxacin (Cip) via the mucosa. METHODS: Mucosa absorption experiment and deposit effect were made on a two cells diffusion apparatus in vitro to calculate permeation coefficients. RESULTS: With increasing of the concentration of Cip, the permeation coefficient of mucosa absorption showed a increasing tendency, but deposit effect declined significantly. After using l menthol, the permeation coefficient of Cip showed a declining tendency. Especially at 0.2 percent concentration of l menthol, the decrease level was more obvious than other groups (P 0.01 ), but its deposit effect was the largest. CONCLUSION: L Menthol could decrease permeation coefficient of mucosa absorption of Cip and obviously enhance deposit effect of Cip.

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What this paper is about

AIM: To investigate the effect of l menthol on the absorption of ciprofloxacin (Cip) via the mucosa. METHODS: Mucosa absorption experiment and deposit effect were made on a two cells diffusion apparatus in vitro to calculate permeation coefficients. RESULTS: With increasing of the concentration of Cip, the permeation coefficient of mucosa absorption showed a increasing tendency, but deposit effect declined significantly. After using l menthol, the permeation coefficient of Cip showed a declining tendency. Especially at 0.2 percent concentration of l menthol, the decrease level was more obvious than other groups (P 0.01 ), but its deposit effect was the largest. CONCLUSION: L Menthol could decrease permeation coefficient of mucosa absorption of Cip and obviously enhance deposit effect of Cip.

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Available abstract

AIM: To investigate the effect of l menthol on the absorption of ciprofloxacin (Cip) via the mucosa. METHODS: Mucosa absorption experiment and deposit effect were made on a two cells diffusion apparatus in vitro to calculate permeation coefficients. RESULTS: With increasing of the concentration of Cip, the permeation coefficient of mucosa absorption showed a increasing tendency, but deposit effect declined significantly. After using l menthol, the permeation coefficient of Cip showed a declining tendency. Especially at 0.2 percent concentration of l menthol, the decrease level was more obvious than other groups (P 0.01 ), but its deposit effect was the largest. CONCLUSION: L Menthol could decrease permeation coefficient of mucosa absorption of Cip and obviously enhance deposit effect of Cip.

Key concepts: Menthol, Permeation, Chemistry, Absorption (acoustics), Partition coefficient, Chromatography, In vitro, Biochemistry

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