2011•Zhonghua zhongliu fangzhi zazhiRequires access

Expression and significance of MMP-2,MMP-9 and VEGF in colon carcinoma tissues

Xilin Song

Abstract

OBJECTIVE:To analyze the relationships of MMP-2,MMP-9 and VEGF expression in and colon carcinoma tumor and lymph nodes tissues,and to investigate the clinical significance.METHODS: The expressions of MMP-2,MMP-9 and VEGF were measured by immunohistochemistry and ELISA in the resected specimens from 60 patients with colon carcinoma and 25 normal controls.RESULTS: The positive rate of MMP-2,MMP-9 and VEGF in the colonic carcinoma tissues were 81.6%,78.3% and 90.0%,which were significantly higher than those of controls(P0.05).The positive rate of MMP-2,MMP-9 and VEGF were significantly correlated with TNM stage and lymph node metastasis(P0.05).CONCLUSION: MMP-2,MMP-9 and VEGF expression in colon carcinoma increases markedly and plays an important role in progression of colon carcinoma.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Matrix metalloproteinase, Immunohistochemistry, Colon carcinoma, Medicine, VEGF receptors, Carcinoma, Stage (stratigraphy), Colorectal cancer