Efficacy of BCG-PSN Combined with Narrow-band Ultraviolet B Irradiation for the Treatment of Atopic Dermatitis and its Role on Peripheral Blood Eosinophil

Objective To observe the efficacy of BCG-PSN combined with narrow-band ultraviolet B irradiation for the treatment of atopic dermatitis and the variations of the peripheral blood eosinophil count in patients, which can give guidance for the treatment of atopic dermatitis. Methods Seventy-eight patients with atopic dermatitis were randomly divided into trial group and control group, and each group had 39 patients. The trial group was treated with BCG-PSN and narrow-band ultraviolet B irradiation, and the control group was treated with narrow-band ultraviolet B irradiation only, the treatment course was 2 weeks for both groups. The severity of stroke patients with atopic dermatitis was evaluated according to SCORAD scoring system; the extent of pruritus was evaluated on VAS, and levels of peripheral blood eosinophil between the two groups were detected and compared before and after. Results After 8 weeks treatment, the rates of efficacy were 82.05% in the trial group and 53.85% in the control group, the level of peripheral blood eosinophil (221.65 ± 43.51) was significantly lower than the control group (294.35 ± 60.21) and before treatment (376.21 ± 119.34), the differences were statistically significant (P 0.01); but the levels of peripheral blood eosinophil (376.21 ± 119.34 and 353.32 ± 131.33) in patients before treatment did not have statistically significant difference (P 0.05). Conclusion BCG-PSN combined with narrow-band ultraviolet B irradiation can improve efficacy in atopic dermatitis and reduce the peripheral blood eosinophil count significantly.