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2011•Chinese Journal of New Drugs and Clinical RemediesRequires access

Effects of sevoflurane inhalation anesthesia on hippocampal neurogenesis and cognitive function development in neonatal rats

Liao Liuc

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Abstract

AIM To study the effects of sevoflurane inhalation anesthesia on hippocampal neurogenesis and cognitive function development in neonatal rats.METHODS Sixty-four 7-day-old neonatal SD rats were randomly divided into four groups(16 rats in each group).Rats in the group A,B,C and D were respectively inhaled with 40% oxygen,1.0%,2.0% and 4.0% sevoflurane for 1 hour respectively.Eight rats in each group were labeled by intraperitoneal injections of bromodeoxyuridine(BrdU)50 mg·kg-1 every two days and proliferating cells were quantified by immunohistochemistry score(IHS)at d 14.The other eight rats in each group were subjected to Morris water maze to access cognitive function at age of 7 weeks after anesthesia.RESULTS The IHS of group B,C and D(2.74 ± 0.40,2.30 ± 0.20,2.30 ± 0.31)were lower than that of group A(4.00 ± 0.36,P 0.05).Escape latency and probe time of group B,C and D were significantly longer than those of group A(P 0.05)and showed a dose-dependent manner.CONCLUSION Inhalation anesthesia of sevoflurane may interfere the hippocampal neurogenesis and development of cognitive function in neonatal rats.

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AIM To study the effects of sevoflurane inhalation anesthesia on hippocampal neurogenesis and cognitive function development in neonatal rats.METHODS Sixty-four 7-day-old neonatal SD rats were randomly divided into four groups(16 rats in each group).Rats in the group A,B,C and D were respectively inhaled with 40% oxygen,1.0%,2.0% and 4.0% sevoflurane for 1 hour respectively.Eight rats in each group were labeled by intraperitoneal injections of bromodeoxyuridine(BrdU)50 mg·kg-1 every two days and proliferating cells were quantified by immunohistochemistry score(IHS)at d 14.The other eight rats in each group were subjected to Morris water maze to access cognitive function at age of 7 weeks after anesthesia.RESULTS The IHS of group B,C and D(2.74 ± 0.40,2.30 ± 0.20,2.30 ± 0.31)were lower than that of group A(4.00 ± 0.36,P 0.05).Escape latency and probe time of group B,C and D were significantly longer than those of group A(P 0.05)and showed a dose-dependent manner.CONCLUSION Inhalation anesthesia of sevoflurane may interfere the hippocampal neurogenesis and development of cognitive function in neonatal rats.

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Available abstract

AIM To study the effects of sevoflurane inhalation anesthesia on hippocampal neurogenesis and cognitive function development in neonatal rats.METHODS Sixty-four 7-day-old neonatal SD rats were randomly divided into four groups(16 rats in each group).Rats in the group A,B,C and D were respectively inhaled with 40% oxygen,1.0%,2.0% and 4.0% sevoflurane for 1 hour respectively.Eight rats in each group were labeled by intraperitoneal injections of bromodeoxyuridine(BrdU)50 mg·kg-1 every two days and proliferating cells were quantified by immunohistochemistry score(IHS)at d 14.The other eight rats in each group were subjected to Morris water maze to access cognitive function at age of 7 weeks after anesthesia.RESULTS The IHS of group B,C and D(2.74 ± 0.40,2.30 ± 0.20,2.30 ± 0.31)were lower than that of group A(4.00 ± 0.36,P 0.05).Escape latency and probe time of group B,C and D were significantly longer than those of group A(P 0.05)and showed a dose-dependent manner.CONCLUSION Inhalation anesthesia of sevoflurane may interfere the hippocampal neurogenesis and development of cognitive function in neonatal rats.

Key concepts: Sevoflurane, Hippocampal formation, Inhalation, Anesthesia, Neurogenesis, Morris water navigation task, Medicine, Hippocampus

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