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2011•Zhongguo linchuang yixueRequires access

The Detection and Significance of CD4~+CD25~+CD127~(lo/-)Tregs in Peripheral Blood CD4+T Cells of Healthy and Asthma Patients during Exacerbation and Remission

Rensong Ye

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Abstract

Objective:To investigate the relationship between the expression levels of CD4+CD25+CD127lo/-Tregs in peripheral blood of asthma patients during exacerbation or remission.Methods: A total of 2 ml peripheral blood were collected in healthy or asthma patients during exacerbation and remission.The percentage of CD4+CD25+CD127lo/-Tregs in CD4+T cells by flow cytometry were detected.Results: A significant decrease of the percentage of CD4+CD25+CD127lo/-Tregs in CD4+T cells was observed in exacerbation and remission groups compared with control group(P0.05).This was also detected in exacerbation group compared with remission group(P0.05).Conclusions: The CD4+CD25+CD127lo/-Tregs play a key role in the pathogenesis of asthma and its decrease,which may lead to immune dysfunction,may be involved in the mechanisms of asthma.

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What this paper is about

Objective:To investigate the relationship between the expression levels of CD4+CD25+CD127lo/-Tregs in peripheral blood of asthma patients during exacerbation or remission.Methods: A total of 2 ml peripheral blood were collected in healthy or asthma patients during exacerbation and remission.The percentage of CD4+CD25+CD127lo/-Tregs in CD4+T cells by flow cytometry were detected.Results: A significant decrease of the percentage of CD4+CD25+CD127lo/-Tregs in CD4+T cells was observed in exacerbation and remission groups compared with control group(P0.05).This was also detected in exacerbation group compared with remission group(P0.05).Conclusions: The CD4+CD25+CD127lo/-Tregs play a key role in the pathogenesis of asthma and its decrease,which may lead to immune dysfunction,may be involved in the mechanisms of asthma.

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Available abstract

Objective:To investigate the relationship between the expression levels of CD4+CD25+CD127lo/-Tregs in peripheral blood of asthma patients during exacerbation or remission.Methods: A total of 2 ml peripheral blood were collected in healthy or asthma patients during exacerbation and remission.The percentage of CD4+CD25+CD127lo/-Tregs in CD4+T cells by flow cytometry were detected.Results: A significant decrease of the percentage of CD4+CD25+CD127lo/-Tregs in CD4+T cells was observed in exacerbation and remission groups compared with control group(P0.05).This was also detected in exacerbation group compared with remission group(P0.05).Conclusions: The CD4+CD25+CD127lo/-Tregs play a key role in the pathogenesis of asthma and its decrease,which may lead to immune dysfunction,may be involved in the mechanisms of asthma.

Key concepts: Exacerbation, Medicine, IL-2 receptor, Asthma, Pathogenesis, Peripheral blood, Flow cytometry, Immunology

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The Detection and Significance of CD4~+CD25~+CD127~(lo/-)Tregs in Peripheral Blood CD4+T Cells of Healthy and Asthma Patients during Exacerbation and Remission — Research Paper | ScholarLens