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Action of sulfonylurea on mRNA levels of components of ATP-sensitive potassium channel(SUR1,SUR2 and Kir6.2)in rat brain

FU Zu-zh

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Abstract

The effects of streptozotocin-induced diabetes or long-term glyburide administration on mRNA levels of components of ATP-sensitive potassium channel(SUR1,SUR2,Kir6.2)in rat brain were observed. Streptozotocin-induced diabetes itself did not affect the mRNA levels of SUR1,SUR2,and Kir6.2 in the brain, and glyburide-treatment increased the Kir6.2 mRNA level in brain by 23% in non-diabetic rats than those in normal control but did not change SUR1 and SUR2 levels.The effects of glyburide on SUR1,SUR2 and Kit6.2 mRNA levels did not manifest in brain of diabetic rats.

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What this paper is about

The effects of streptozotocin-induced diabetes or long-term glyburide administration on mRNA levels of components of ATP-sensitive potassium channel(SUR1,SUR2,Kir6.2)in rat brain were observed. Streptozotocin-induced diabetes itself did not affect the mRNA levels of SUR1,SUR2,and Kir6.2 in the brain, and glyburide-treatment increased the Kir6.2 mRNA level in brain by 23% in non-diabetic rats than those in normal control but did not change SUR1 and SUR2 levels.The effects of glyburide on SUR1,SUR2 and Kit6.2 mRNA levels did not manifest in brain of diabetic rats.

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Available abstract

The effects of streptozotocin-induced diabetes or long-term glyburide administration on mRNA levels of components of ATP-sensitive potassium channel(SUR1,SUR2,Kir6.2)in rat brain were observed. Streptozotocin-induced diabetes itself did not affect the mRNA levels of SUR1,SUR2,and Kir6.2 in the brain, and glyburide-treatment increased the Kir6.2 mRNA level in brain by 23% in non-diabetic rats than those in normal control but did not change SUR1 and SUR2 levels.The effects of glyburide on SUR1,SUR2 and Kit6.2 mRNA levels did not manifest in brain of diabetic rats.

Key concepts: Kir6.2, Sulfonylurea receptor, Endocrinology, Internal medicine, ATP-sensitive potassium channel, Streptozotocin, Potassium channel, Sulfonylurea

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Action of sulfonylurea on mRNA levels of components of ATP-sensitive potassium channel(SUR1,SUR2 and Kir6.2)in rat brain — Research Paper | ScholarLens