Comparision of genome between Mycobacterium bovis and Mycobacterium tuberculosis

Through the comparision of genome between the Mycobacterium bovis and Mycobacterium tuberculosis,it is concluded that the homology of Mycobacterium bovis and Mycobacterium tuberculosis are 99.95% respectively,but there are 11 deletants(range,from 1kb to 12.7kb in the genome of the Mycobacterium bovis.The absence of genetic information resulted in reduction of genome in Mycobacterium bovis.There are 2437 single-nucleotide polymorphisms(SNPs) between the Mycobacterium bovis and Mycobacterium tuberculosis H37Rv,2423 SNPs,between the Mycobacterium bovis and Mycobacterium tuberculosisCDC1551.The extent of variation is obvious on Codocyte cellwall and secreted protein between the two.The finding reveals the genetic relationship between Mycobacterium bovis and Mycobacterium tuberculosis,which offers a theoretical basis for Mycobacterium vaccine and diagnostic reagent,and is of great significance for the prevention and treatment of Bovine pulmonary tuberculosis.