Application of 0.5% Hypobaric Ropivacaine and Bupivacaine in Combined Spinal-Epidural Anesthesia in Elderly Patients Undergoing Hip Replacement at Lateral Position

Objective:To investigate the application safety and effect of combined spinal-epidural anesthesia (CSEA) with 0.5% hypobaric ropivacaine for the elderly with serious complications undergoing lateral position of hip replacement. Methods:Eighty elderly patients scheduled for lateral position of hip replacement with CSEA were randomly divided into group R and group B,which were anaesthetized by ropivacaine and bupivacaine respectively. Results:Onset time and time to maximal level of sensory block and motor block were longer in group R than those in group B respectively,while duration time of analgesia and maximal Bromage score in group R were shorter (all P0.05). Compared with those in group B,systolic blood pressure (SBP),diastolic blood pressure (DBP),heart rate (HR) and pulse oxygen saturation (SpO2) were more stable and side effects were less in group R (all P0.05). The concentrations of plasma rennin activity (PRA),angiotensin Ⅱ(ATⅡ) and aldosterone (ALD) in group R were higher than those in group B respectively (all P0.05). Conclusion:Unilateral CSEA with 0.5% hypobaric ropivacaine is safe and effective for the elderly with cardiopulmonary function incompetence and blood hyperviscosity undergoing hip replacement.