Prevention of Jarisch-Herxheimer reaction in women of pregnant syphilis by using modified progressively increasing low-dose penicillin

Objective To observe the effect of modified progressively increasing low-dose penicillin in prevention of Jarisch-Herxheimer reaction in women of pregnant syphilis.Methods Two hundred pregnant syphilis cases inclduingf early syphilis or latent syphilis were divided into 2 groups randomly and the effect in prevention of Jariseh-Herxheimer reaction was observed.Results The 100 cases in treatment group were treated with modified increasing progressively low-dose penicillin and Jarisch-Herxheimer reaction occurred to 9 cases with an incidence of 9%.While another 100 cases in the control group were treated with progressively increasing low-dose of penicillin and Jarisch-Herxheimer reaction occurred to 8 cases with an incidence of 8%.The general incidence rate of Jarisch-Herxheimer reaction was 8.5%.Conclusions No significant differences of in incidence rate of Jarisch-Herxheimer reaction were observed between 2 groups,but the method of treatment group was more practical.