The study on colon myenteric plexus change of slow transit constipation in rats

Objective To observe the changes in colon myenteric plexus of rhubarb-induced slow-transit constipation in rats,to investigate the correlation between rhubarb and the development of the disease.Methods The rats were fed with rhubarb to make the animal models of slow transit constipation.The transfer function of the colon and somatostatin(som),P material(sp)expression,colon myenteric plexus pathological and ultrastructural changes were detected.Results The rhubarb model group slowed colonic transit function;mucosal chronic inflammation,a large number of full-thickness eosinophil infiltration;myenteric plexus nerve cell degeneration and increase,and colon myenteric plexus was not found in the interstitial Cajal cells and rat colon myenteric plexus SOM,and the content of SP was significantly decreased,as compared with that of control group(P0.01).Conclusion The rhubarb anthraquinones can damage cathartic colon wall plexus,reduce the function of colonic transit.Therefore,for the patients with slow transit constipation,the long-term application of such substances should be avoided.