Expression and significance of MMP-9 and VEGF in non-small cell lung carcinoma

Objective To investigate the protein expressions of MMP-9 and VEGF,observe their relationship and clinical significance on development and metastasis of non-small cell lung carcinoma.Methods We detected the protein expressions of MMP-9 and VEGF by IHC in the non-small cell lung carcinoma(86 cases) and normal lung tissues(60 cases).Their expression relationship and different pathological characters in the non-small cell lung carcinoma were analyzed.Results The protein expressions of MMP-9 and VEGF were higher in the neoplasm than in normal lung tissues.Their expressions were correlated with diameter,pleura invasion,differentiation and lymph node metastasis.Positive correlation between MMP-9 and VEGF protein were found in neoplasm.The expressions of MMP-9 and VEGF were correlated with prognosis.Conclusion The higher expressions of MMP-9 and VEGF are found in non-small cell lung carcinoma.The combined detection of MMP-9 and VEGF may be helpful for prognosis of neoplasm.