THE RELATIONS OF SERUM HOMOTYPE CYSTEINE WITH URINE ALBUMIN AND INSULIN SENSITIVITY IN PATIENTS WITH DIABETES TYPE 2

Objective To study the relationship between fasting serum levels of homocysteine and urine albumin ,sensitivity of insulin in patients with type 2 diabetic nephropathy. Methods 98 cases with type 2 diabetic mellitus were subdivided into 4 groups according the level of urine albumin excretion rate,just group A(UAER30 mg/24 h),group B (30 mg/24 h≤UAER300 mg/24 h) and group C(UAER≥300 mg/24 h). 30 healthy cases were defined group CON. Hcy,FPG,FINS,HbA1c,UAER and insulin sensitivity index of every group were evaluated. Results The level of serum Hcy of A,B and C was significantly higher than that of group CON(p0.05),and the level of serum Hcy among different UAER value in three groups of diabetic patients: group C higher than group A and B,group B higher than group A,the differences were significant(p0.05). There was markedly positive correlation between Hcy and UAER and negative correlation between Hcy and ISI(p0.01).Conclusion There was markedly positive correlation between Hcy and UAER in patients with type 2 DN,the high level of Hcy correlated with descending of sensitivity of insulin. To control the UAER and enhance sensitivity of insulin can regulate level of Hcy,then preventing the capillary complication of diabetes.