Effects and potential side effects of Lurong Jiangu capsule as a novel candidate for the treatment of primary osteoporosis: a clinical trial

Objective To investigate the effects and potential side effects of Lurong Jiangu capusle as a novel candidate for the treatment of primary osteoporosis.Methods 60 patients with primary osteoporosis were randomly divided into group A and group B. Group A was given Lurong Jiangu capusle and group B was treated with Gushukang granule for 12 months。Before and after the treatment, the patients were subjected to routine examination of blood, urine and stool. Electrocardiogram, function of liver and kidney, serum electrolytes and bone mineral density (BMD) of the L 2-4 vertebrae were evaluated pre-and post-treatment, subjective symptoms such as pain in the back and weakness in the knee were assessed during the treatment.Results BMD increased and subjective symptoms were relieved in 82.14% of patients in group A and 67.86% in group B. No significant side effects on heart, liver, kidney and the homeostasis of blood and serum electrolytes were observed in patients treated with Lurong Jiangu capusle. Moreover, Lurong Jiangu capusle improved blood supply to the heart.Conclusion Lurong Jiangu capusle is a well tolerated, effective novel candidate for the treatment of primary osteoporosis.