Relationship between malnutrition and serum leptin,tumor necrosis factor-α and interleukin-6 levels in patients with chronic obstruction pulmonary disease

Objective To observe relationship between malnutrition and serum leptin,tumor necrosis factor-a and interleukin-6(IL-6) levels in patients with stable chronic obstruction pulmonary disease(COPD).Methods Serum leptin,TNF-α and IL-6 concentrations of 50 COPD patients in stationary phase(divided into two groups:25 patients in malnutrition group;25 patients in non malnutrition group) and 25 healthy volunteers were tested by ELISA.The ideal body mass percentage(NBM%),body mass index(BMl),triceps skin-fold thickness(TSF),mid-upper arm circumference(MAC) and serum albumin(ALB) were measured in all patients.The correlation between leptin,TNF-α,IL-6 concentrations and nutritional parameters was analyzed.Results Serum TNF-α and IL-6 concentrations in malnutrition patients were evidently higher than in non malnutrition patients.The letin level in malnutrition patients was significantly lower than in non malnutrition patients,(4.74±0.92) μg/L vs(6.96±0.75) μg/L(P0.01).Serum leptin concentrations were significantly positive correlated with some nutritional parameters such as NBM%,BMI,TSF,AMC in all three groups(P0.01).Serum TNF-α concentrations were positive correlated with NBM% and BMI in malnutrition patients(P0.05),while serum TNF-α concentrations were not correlated with other parameters.Serum IL-6 concentrations were not correlated with serum leptin,TNF-α concentrations and nutritional parameters.Conclusion Serum leptin concentration was significantly correlated with nutritional parameters in COPD patients in stationary phase.