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Effect of Adrenomedullin Subcutaneously Administered by Mini-Osmotic Pump on Hypoxic Pulmonary Hypertension in Rats

Ya-guang Ding

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Abstract

Objective To study the modulation effect of adrenomedullin (ADM) on hypoxia pulmonary hypertension in rats.Methods Twenty-four male Wistar rats were randomly divided into control group ( n =8), hypoxic group ( n =8), hypoxic with ADM group ( n =8). ADM was subcutaneously administered into rats of hypoxic with ADM group by mini-osmotic pump (300 ng/h). After two weeks hypoxic challenge, systolic pulmonary arterial pressure (sPAP) and mean pulmonary arterial pressure (mPAP) were evaluated by a right cardiac catheterization procedure. Mean systemic artery pressure (mSAP) was measured. The ratio of right ventricular mass to left ventricular plus septal mass [RV/(LV+S)] was detected.Results sPAP, mPAP and RV/(LV+S) significantly increased in hypoxic rats compared with controls ( P 0.01, respectively). sPAP, mPAP and RV/(LV+S) significantly decreased in rats of hypoxic with ADM group compared with those of hypoxic group ( P 0.01, respectively). No significant difference was found in mSAP among the three groups.Conclusion ADM subcutaneously administered by mini-osmotic pump may alleviate the development of hypoxic pulmonary hypertension in rats.

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Objective To study the modulation effect of adrenomedullin (ADM) on hypoxia pulmonary hypertension in rats.Methods Twenty-four male Wistar rats were randomly divided into control group ( n =8), hypoxic group ( n =8), hypoxic with ADM group ( n =8). ADM was subcutaneously administered into rats of hypoxic with ADM group by mini-osmotic pump (300 ng/h). After two weeks hypoxic challenge, systolic pulmonary arterial pressure (sPAP) and mean pulmonary arterial pressure (mPAP) were evaluated by a right cardiac catheterization procedure. Mean systemic artery pressure (mSAP) was measured. The ratio of right ventricular mass to left ventricular plus septal mass [RV/(LV+S)] was detected.Results sPAP, mPAP and RV/(LV+S) significantly increased in hypoxic rats compared with controls ( P 0.01, respectively). sPAP, mPAP and RV/(LV+S) significantly decreased in rats of hypoxic with ADM group compared with those of hypoxic group ( P 0.01, respectively). No significant difference was found in mSAP among the three groups.Conclusion ADM subcutaneously administered by mini-osmotic pump may alleviate the development of hypoxic pulmonary hypertension in rats.

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Available abstract

Objective To study the modulation effect of adrenomedullin (ADM) on hypoxia pulmonary hypertension in rats.Methods Twenty-four male Wistar rats were randomly divided into control group ( n =8), hypoxic group ( n =8), hypoxic with ADM group ( n =8). ADM was subcutaneously administered into rats of hypoxic with ADM group by mini-osmotic pump (300 ng/h). After two weeks hypoxic challenge, systolic pulmonary arterial pressure (sPAP) and mean pulmonary arterial pressure (mPAP) were evaluated by a right cardiac catheterization procedure. Mean systemic artery pressure (mSAP) was measured. The ratio of right ventricular mass to left ventricular plus septal mass [RV/(LV+S)] was detected.Results sPAP, mPAP and RV/(LV+S) significantly increased in hypoxic rats compared with controls ( P 0.01, respectively). sPAP, mPAP and RV/(LV+S) significantly decreased in rats of hypoxic with ADM group compared with those of hypoxic group ( P 0.01, respectively). No significant difference was found in mSAP among the three groups.Conclusion ADM subcutaneously administered by mini-osmotic pump may alleviate the development of hypoxic pulmonary hypertension in rats.

Key concepts: Adrenomedullin, Medicine, Pulmonary hypertension, Pulmonary artery, Hypoxia (environmental), Internal medicine, Cardiology, Anesthesia

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