2003•Zhonghua neifenmi daixie zazhiRequires access

Expressions of leptin receptor mRNA and neuropeptide Y mRNA in the hypothalamic arcuate nucleus of obese rat induced by high fat diet

Dajin Zou

Abstract

The rat model of obesity was induced by high fat diet and in situ hybridization was performed with oligonucleotide probes.The results showed that expressions of leptin receptor mRNA and neuropeptide Y mRNA were significantly increased, suggesting that these increments might be related to leptin resistance.

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Available abstract

Key concepts: Internal medicine, Endocrinology, Leptin, In situ hybridization, Arcuate nucleus, Leptin receptor, Messenger RNA, Neuropeptide Y receptor