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2001•Journal of Anhui Traditional Chinese Medical CollegeRequires access

EXPERIMENTAL RESEARCH ON THERAPEUTIC EFFECT OF GUSHENG PILL ON FEMORAL HEAD NECROSIS AT EARLY STAGE AFTER FEMORAL NECK FRACTURE

Jian Wu

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Abstract

Objective:To probe into the mechanism of Gusheng Pill,a traditional Chinese preparation,in the treatment of femoral head necrosis at the early stage after femoral neck fracture.Method:White rabbits' models of femoral head necrosis at the early stage was made according to Kenzora's method.The rabbits in treatment group were fed with GSP for 4 weeks,then,were killed by decapitation.Rabbit femoral heads were taken out and the mean bone lacuna rate was observed under microscope.The whole blood viscosity,plasma ratio viscosity,hematocrit,blood sedimentation,reduction viscosity,collecting exponent and fibrin were assayed with radioimmunoassay.Rusult:GSP had good effect on decreasing mean bone lacuna rate and improving the state of blood rheology.Conclusion:GSP has the therapeutic effect by reversing the ischemic state of femoral head and promoting the renovation of femoral head necrosis.

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What this paper is about

Objective:To probe into the mechanism of Gusheng Pill,a traditional Chinese preparation,in the treatment of femoral head necrosis at the early stage after femoral neck fracture.Method:White rabbits' models of femoral head necrosis at the early stage was made according to Kenzora's method.The rabbits in treatment group were fed with GSP for 4 weeks,then,were killed by decapitation.Rabbit femoral heads were taken out and the mean bone lacuna rate was observed under microscope.The whole blood viscosity,plasma ratio viscosity,hematocrit,blood sedimentation,reduction viscosity,collecting exponent and fibrin were assayed with radioimmunoassay.Rusult:GSP had good effect on decreasing mean bone lacuna rate and improving the state of blood rheology.Conclusion:GSP has the therapeutic effect by reversing the ischemic state of femoral head and promoting the renovation of femoral head necrosis.

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Available abstract

Objective:To probe into the mechanism of Gusheng Pill,a traditional Chinese preparation,in the treatment of femoral head necrosis at the early stage after femoral neck fracture.Method:White rabbits' models of femoral head necrosis at the early stage was made according to Kenzora's method.The rabbits in treatment group were fed with GSP for 4 weeks,then,were killed by decapitation.Rabbit femoral heads were taken out and the mean bone lacuna rate was observed under microscope.The whole blood viscosity,plasma ratio viscosity,hematocrit,blood sedimentation,reduction viscosity,collecting exponent and fibrin were assayed with radioimmunoassay.Rusult:GSP had good effect on decreasing mean bone lacuna rate and improving the state of blood rheology.Conclusion:GSP has the therapeutic effect by reversing the ischemic state of femoral head and promoting the renovation of femoral head necrosis.

Key concepts: Femoral head, Medicine, Femoral neck, Hematocrit, Pentoxifylline, Erythrocyte sedimentation rate, Surgery, Necrosis

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EXPERIMENTAL RESEARCH ON THERAPEUTIC EFFECT OF GUSHENG PILL ON FEMORAL HEAD NECROSIS AT EARLY STAGE AFTER FEMORAL NECK FRACTURE — Research Paper | ScholarLens