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2005•Chinese Journal of Birth Health & HeredityRequires access

The application of comparative genomic hybridization

Cui Ying-xi

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Abstract

The majority of human tumors as well as many developmental abnormalities harbor chromosomal imbalances,many of which result from the gain and/or loss of genomic material.Conventional comparative genomic hybridization(CGH) has been used extensively to map DNA copy number changes to chromosomal positions.The recent introduction of microarray comparative genomic hybridization(CGHa) provides a powerful tool to precisely detect and quantify genomic subtle deletions or duplications.This paper reviews the principle and application of CGH and CGHa.

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What this paper is about

The majority of human tumors as well as many developmental abnormalities harbor chromosomal imbalances,many of which result from the gain and/or loss of genomic material.Conventional comparative genomic hybridization(CGH) has been used extensively to map DNA copy number changes to chromosomal positions.The recent introduction of microarray comparative genomic hybridization(CGHa) provides a powerful tool to precisely detect and quantify genomic subtle deletions or duplications.This paper reviews the principle and application of CGH and CGHa.

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Available abstract

The majority of human tumors as well as many developmental abnormalities harbor chromosomal imbalances,many of which result from the gain and/or loss of genomic material.Conventional comparative genomic hybridization(CGH) has been used extensively to map DNA copy number changes to chromosomal positions.The recent introduction of microarray comparative genomic hybridization(CGHa) provides a powerful tool to precisely detect and quantify genomic subtle deletions or duplications.This paper reviews the principle and application of CGH and CGHa.

Key concepts: Comparative genomic hybridization, Biology, genomic DNA, Computational biology, Genetics, Microarray, Copy-number variation, Genome

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