The value of 64-slice spiral CT perfusion imaging and CT angiography in acute ischemic stroke

Objective To evaluate the value of combined use of CT perfusion(CTP) imaging and CT angiography(CTA) in acute ischemic stroke.Methods Twenty-two acute ischemic stroke patients were included. The regions of interest(ROI) of the patients were selected within 24 hours of onset by 64-slice spiral CT.rCBV,rCBF,MTT and TTP were used as hemodynamic parameters to compare research regions with the counterparts.Specificity and sensitivity of the CTP and CTA were analyzed with gold standard of MRI results.The differences of MTT,CBF,CBV and TTP between the affected cores and supposed penumbra were also analyzed.Results CBF of the research area reduced,and MTT increased.Matched-sample t test of interest area and control area showed P0.01.Sensitivity of CTP plus CTA in identifying ischemic area was 90.1% and the specificity was 100%.Conclusion CTPI plus CTA may provide radiological evidence in predicting development,severity,prognosis of acute ischemic stroke patients.