Correlation of dynamic CT indices with proliferating cell nuclear antigen expression in brain astrocytoma

Objective To explore the correlation of dynamic CT indices with proliferating cell nuclear antigen(PCNA) expression.Methods Thirty-eight cases of astrocytoma proven by operation and pathology were reviewed.Based on time-density curve,the dynamic CT indices,such as TBR_(p),TBR_(L),S(ascending slope of time-density curve),AR(area under the time-density curve) were calculated.PCNA on the tumor specimens was stained with immunohistochemical method.PCNA index was measured and compared with dynamic CT indices.Results PCNA expression in astrocytoma was well correlated with the pathological grade and clinical prognosis.There was significant statistical difference in TBR_(p),TBR_(L),S,AR between grade Ⅲ-Ⅳ and grade Ⅰ-Ⅱ(P0.05).Besides,TBR_(p),TBR_(L),S,AR had positive correlation with PCNA index.Conclusion The extent and pattern of enhancement in astrocytoma on dynamic CT scan have a close relation with PCNA expression.