Diagnostic Values of CT-Guided Lung Biopsy of Malignant Lesions Based on Three Different Sampling Methods

Objective To compare the values of three sampling methods based on the diagnostic accuracy of malignant lesions of the lungs.Methods Totally 206 patients with lung masses or nodules underwent CT-guided percutaneous lung biopsy.And 138 of them were diagnosed as having pulmonary malignant lesions by surgical pathology,clinical features and follow-up,including cutting biopsy group of 47 patients,needle aspiration group of 40 patients,and cutting plus needle aspiration biopsy 50 patients.The diagnostic accuracies of malignant lesions of the lungs by the three sampling methods were compared.Results The specificity and positive predictive value of all the three methods were 1.0000;Sensitivities of the three different methods were 0.7500,0.6875and 0.9231 respectively;and the negative predictive values were 0.8571,0.7500 and 0.9565 respectively,Youden index were 0.7500,0.6875 and 0.9231 respectively.For malignant lesions on histopathological type,the accuracy rate of CT-guided percutaneous lung biopsy was 69.57%(96/138),The accurate diagnosis rates in three different methods were 72.34%(34/47),44.44%(20/45) and 91.30%(42/46) respectively(χ2=23.8515,P0.001).Conclusion In CT-guided percutaneous lung biopsy,cutting plus needle aspiration biopsy has higher rates in diagnosis accuracy of lung malignant lesions and the histological type of pathology than single cutting biopsy or needle aspiration.