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2013•Medical Innovation of ChinaRequires access

Clinical Observation of Fludarabine or Fludarabine Combined with Cyclophosphamide in Chronic Lymphocytic Leukemia

Shen Lian-yu

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Abstract

Objective:To observe the therapeutic effects and adverse reactions of fludarabine or fludarabine combined cyclophosphamide in chronic lymphocytic leukemia(CLL).Method:33 patients with CLL were divided into three treatment group,each group was given fludarabine or fludarabine combined cyclophosphamide or CHOP regimen.Compared the the rate of complete remission(CR),overall remission(OR)and adverse reactions.Result:F and FC regimen resulted in significantly were higher CR rate than that in CHOP regimen(P 0.05).The rate of complete remission(CR)of FC regimen was higher than that of fludarabine regimen.No significant difference was found in side effects between three regimens(P 0.05).Conclusion:Fludarabine in chronic lymphocytic leukemia(CLL)has a much better therapeutic effect than CHOP regimen.FC regimen can give higher CR rate as compared with F regimen.

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What this paper is about

Objective:To observe the therapeutic effects and adverse reactions of fludarabine or fludarabine combined cyclophosphamide in chronic lymphocytic leukemia(CLL).Method:33 patients with CLL were divided into three treatment group,each group was given fludarabine or fludarabine combined cyclophosphamide or CHOP regimen.Compared the the rate of complete remission(CR),overall remission(OR)and adverse reactions.Result:F and FC regimen resulted in significantly were higher CR rate than that in CHOP regimen(P 0.05).The rate of complete remission(CR)of FC regimen was higher than that of fludarabine regimen.No significant difference was found in side effects between three regimens(P 0.05).Conclusion:Fludarabine in chronic lymphocytic leukemia(CLL)has a much better therapeutic effect than CHOP regimen.FC regimen can give higher CR rate as compared with F regimen.

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Available abstract

Objective:To observe the therapeutic effects and adverse reactions of fludarabine or fludarabine combined cyclophosphamide in chronic lymphocytic leukemia(CLL).Method:33 patients with CLL were divided into three treatment group,each group was given fludarabine or fludarabine combined cyclophosphamide or CHOP regimen.Compared the the rate of complete remission(CR),overall remission(OR)and adverse reactions.Result:F and FC regimen resulted in significantly were higher CR rate than that in CHOP regimen(P 0.05).The rate of complete remission(CR)of FC regimen was higher than that of fludarabine regimen.No significant difference was found in side effects between three regimens(P 0.05).Conclusion:Fludarabine in chronic lymphocytic leukemia(CLL)has a much better therapeutic effect than CHOP regimen.FC regimen can give higher CR rate as compared with F regimen.

Key concepts: Fludarabine, Medicine, Chronic lymphocytic leukemia, Regimen, Cyclophosphamide, CHOP, Internal medicine, Gastroenterology

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Clinical Observation of Fludarabine or Fludarabine Combined with Cyclophosphamide in Chronic Lymphocytic Leukemia — Research Paper | ScholarLens