Development of Mannose-binding Lectin-associated Serine Protease 1

The mannose-binding lectin pathway is an important pathway of complement activation.In the absence of specific immune responses in vivo or before immune response occurs in body the lectin complement pathway may play a major role in the defense.Mannose-binding lectin-associated serine protease-1(MASP-1) is an central protease of the complement lectin pathway.Mannose-binding lectin(MBL) or ficolin can form compound with Mannose-binding lectin-associated serine protease(MASPs) through its CLR.After its CRD domain recognize and binding to sugars presented on pathogens,MBL or ficolin can activity the zymogens of MASPs,then activate the complement cascade via lectin pathway to play the function of anti-infection by innate immunity.