Comparison of analgesia with morphine and fentanyl after upper abdominal surgery

Objective To compare the clinical effects and adverse effects of morphine and fentanyl with a patient-controlled epidural analgesia(PCEA) delivery system.Methods ASA Ⅰ～Ⅱ 60 patients undergoing upper abdominal operations were randomly divided into two groups with 30 cases respectively.Group A was given 0.01% morphine+0.005% droperidol+0.01% dexamethasone+(0.075%) tetracaine;In group B 0.0004% fentanyl was given to substitute 0.01% morphine in group A.All patients received PCA(total volume 100ml) and devised in LCP Model(load dose 5ml+continuous infusion 2ml/h+PCA Bolus 0.5ml)after operation.MAP,HR,RR,visual analogue scale(VAS),rmaesay sedation scale(RSS) of 4,8,12,24,36,48h were recorded.Results There were no significantly differences between the two groups in the analgesia(P0.05);The incidences of nausea,vomiting,uroschesis and somnolence in group A were higher than that in group B(P0.01 or P0.05).Conclusion When used in postoperative PCEA,morphine and fentanyl can provide same satisfied effect.However,the adverse effects of fentanyl were lower than those of morphine.Fentanyl is more suitable for postoperative analgesia.