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2004•Unpublished venueRequires access

The expression of Bcl-2,Bax and apoptosis after severe brain injury

Weiguo Liu

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Abstract

Objective To discuss the relationship between expression of Bcl-2,Bax and apoptosis after severe brain injury. Methods 50 rats were experimented, which were injured in the brain. TUNEL (terminal-deoxynucleotidyl transferase mediated nick end labeling) and immunohistochemisty were used to detect apoptosis and Bcl-2, Bax expression in all the brain tissue.Results There were significant differences between the injury group and noninjury group with more TUNEL?Bcl-2 Bax positive cells in the injured rats. And in injured rats the value of Bax/Bcl-2 was larger than that in uninjured rats.Conclusion Disequilibrium between the Bcl-2 and Bax may be the reason of promoting apoptosis after severe brain injury.

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What this paper is about

Objective To discuss the relationship between expression of Bcl-2,Bax and apoptosis after severe brain injury. Methods 50 rats were experimented, which were injured in the brain. TUNEL (terminal-deoxynucleotidyl transferase mediated nick end labeling) and immunohistochemisty were used to detect apoptosis and Bcl-2, Bax expression in all the brain tissue.Results There were significant differences between the injury group and noninjury group with more TUNEL?Bcl-2 Bax positive cells in the injured rats. And in injured rats the value of Bax/Bcl-2 was larger than that in uninjured rats.Conclusion Disequilibrium between the Bcl-2 and Bax may be the reason of promoting apoptosis after severe brain injury.

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Available abstract

Objective To discuss the relationship between expression of Bcl-2,Bax and apoptosis after severe brain injury. Methods 50 rats were experimented, which were injured in the brain. TUNEL (terminal-deoxynucleotidyl transferase mediated nick end labeling) and immunohistochemisty were used to detect apoptosis and Bcl-2, Bax expression in all the brain tissue.Results There were significant differences between the injury group and noninjury group with more TUNEL?Bcl-2 Bax positive cells in the injured rats. And in injured rats the value of Bax/Bcl-2 was larger than that in uninjured rats.Conclusion Disequilibrium between the Bcl-2 and Bax may be the reason of promoting apoptosis after severe brain injury.

Key concepts: TUNEL assay, Apoptosis, Medicine, Terminal deoxynucleotidyl transferase, In Situ Nick-End Labeling, BAX Protein, Pathology, Andrology

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