2012•Zhongguo shiyan fangjixue zazhiRequires access
Feasibility of Brain Release of Asarone Hydroxypropyl-β-Cyclodextrin Solution Agent by Intranasal Administration
Tian Jun
Open publisher page 0 citations
Abstract
Objective: To investigate feasibility of brain release of asarone hydroxypropyl-β-cyclodextrin solution agent by intranasal administration.Method:Compared injection and nasal administration perfusion in rabbit of asarone hydroxypropyl-β-cyclodextrin solution agent,feasibility pathway of drug release in brain was investigated after intranasal administration.Result:The content of asarone in blood,olfactory brain,brain and ethmoidal concha had higher quantity by nasal perfusion group than that by intravenous injection group.Conclusion: In pathway process of asarone hydroxypropyl-β-cyclodextrin solution agent enter brain by ethmoidal concha,the content of asarone was higher by nasal perfusion than injection,so it had practical feasibility of brain release by intranasal administration of asarone.