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2011•Journal of Ningxia Medical UniversityRequires access

Association between CYP27B1 Gene Promoter Polymorphisms and Patients with Graves' disease in Ningxia Han People

Linlin Yin

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Abstract

Objective To investigate the association between CYP27B1 gene promoter polymorphisms and patients with Graves' disease in Ningxia Han People.Methods A case control study was performed for CYP27B1(1260 C/A) in the promoter region in 99 patients with GD and 83 healthy individuals.The CYP27B1 genotype all cases and control were examined of by polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP).Results In the promoter(1260) of CYP27B1 gene,the frequencies of genotypes and C/A allele showed no significant difference between cases and controls(P0.05).Conclusion The position 1260 C/A in the promoter of CYP27B1 may be not susceptible to GD in Ningxia Han people.

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What this paper is about

Objective To investigate the association between CYP27B1 gene promoter polymorphisms and patients with Graves' disease in Ningxia Han People.Methods A case control study was performed for CYP27B1(1260 C/A) in the promoter region in 99 patients with GD and 83 healthy individuals.The CYP27B1 genotype all cases and control were examined of by polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP).Results In the promoter(1260) of CYP27B1 gene,the frequencies of genotypes and C/A allele showed no significant difference between cases and controls(P0.05).Conclusion The position 1260 C/A in the promoter of CYP27B1 may be not susceptible to GD in Ningxia Han people.

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Available abstract

Objective To investigate the association between CYP27B1 gene promoter polymorphisms and patients with Graves' disease in Ningxia Han People.Methods A case control study was performed for CYP27B1(1260 C/A) in the promoter region in 99 patients with GD and 83 healthy individuals.The CYP27B1 genotype all cases and control were examined of by polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP).Results In the promoter(1260) of CYP27B1 gene,the frequencies of genotypes and C/A allele showed no significant difference between cases and controls(P0.05).Conclusion The position 1260 C/A in the promoter of CYP27B1 may be not susceptible to GD in Ningxia Han people.

Key concepts: Promoter, Genotype, Restriction fragment length polymorphism, Allele, Gene, Genetics, Polymerase chain reaction, Polymorphism (computer science)

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