Effects of Sulfentanyl and Fentanyl on the plasma of IL-6 in pediatric undergoing surgical repair of congenital cardiac defects with cardiopulmonary bypass

【Objective】To observe the effects of Sulfentanyl and Fentanyl on the plasma of IL-6 in pediatric undergoing surgical repair of congenital cardiac defects with cardiopulminary bypass.【Methods】Twenty-four pediatric patients aged 2~6 years undergoing surgical repair of congenital heart defect were randomized into 2 groups: group Sulfentany(S) and group Fentanyl(F).Anesthesia was induced with Midazolam 0.1 mg/kg and Sulfentanil 0.7μg/kg(in group S) or Fentanyl 5μg/kg(in group F).Tracheal intubation was facilitated with Vecuronium 0.15 mg/ kg.Anesthesia was maintained with Propofol infusion at 6~9 mg/kg/h and intermittent iv boluses of Midazolam,Vecuronium and 3 doses of Sulfentanyl(0.7,1.5,1.5μg/kg) or Fentanyl(5,10,10μg/kg).MAP、HR were recorded at the time of baseline(T1),tracheal intubation(T2),1 min after tracheal intubation(T3),5 min after tracheal intubation(T4),10 min after tracheal intubation(T5),1 min after skin incision(T6),1 min after splitting of sternum(T7).Arterial blood samples were taken before induction of anesthesia(baseline T1),at 1 min after tracheal intubation(T3),1 min after splitting of sternum(T7),immediately after re-warmed(T8),10 min after termination of CPB(T9) and 24 h after operation(T7) for determination of plasma Interleukin-6.【Results】The MAP and HR were maintained in the normal range during operation in both groups.The plasma concentrations of Interleukin-6 were significantly lower in group S than in group F.Plasma Interleukin-6 increased significantly during operation as compared with the baseline before anesthesia in both groups.【Conclusions】Both Sufentanyl and Fentanyl can be safely used in pediatric heart surgery.Sufentanyl can inhibit IL-6 in pediatric patients more effectively during surgical repair of congenital cardiac defect performed under CPB.