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2008•Journal of Jiangxi University of Traditional Chinese MedicineRequires access

Effect of Yiqihuaxian Decoction on Bleomycin-induced Pulmonary Fibrosis in Rats

Jiang Ruijia

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Abstract

Objective: To study the inhibitory effects of Yiqihuaxian(YQHX) decoction on bleomycin-induced pulmonary fibrosis in rats.Methods: Bleomycin was injected intratracheally to make rats lung fibrosis model.The rats were randomly divided into normal group,model group,prednisone group and YQHX decoction group(small dose,large dose).All rats were raised under the same conditions.After 28 days,the rats were killed and the lungs were examined pathologically and the expression of TGF-β1 and the content of hydroxyproline were determined.Results: The changes of pulmonary fibrosis reflected by lung pathological examination,TGF-β1 expression and hydroxyproline content were lighter in the drug therapy groups than those in the model group.Conclusion: YQHX decoction has a certain treating effect on the pulmonary fibrosis induced by bleomycin in rats,possibly through inhibition of TGF-β1 expression.

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What this paper is about

Objective: To study the inhibitory effects of Yiqihuaxian(YQHX) decoction on bleomycin-induced pulmonary fibrosis in rats.Methods: Bleomycin was injected intratracheally to make rats lung fibrosis model.The rats were randomly divided into normal group,model group,prednisone group and YQHX decoction group(small dose,large dose).All rats were raised under the same conditions.After 28 days,the rats were killed and the lungs were examined pathologically and the expression of TGF-β1 and the content of hydroxyproline were determined.Results: The changes of pulmonary fibrosis reflected by lung pathological examination,TGF-β1 expression and hydroxyproline content were lighter in the drug therapy groups than those in the model group.Conclusion: YQHX decoction has a certain treating effect on the pulmonary fibrosis induced by bleomycin in rats,possibly through inhibition of TGF-β1 expression.

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Available abstract

Objective: To study the inhibitory effects of Yiqihuaxian(YQHX) decoction on bleomycin-induced pulmonary fibrosis in rats.Methods: Bleomycin was injected intratracheally to make rats lung fibrosis model.The rats were randomly divided into normal group,model group,prednisone group and YQHX decoction group(small dose,large dose).All rats were raised under the same conditions.After 28 days,the rats were killed and the lungs were examined pathologically and the expression of TGF-β1 and the content of hydroxyproline were determined.Results: The changes of pulmonary fibrosis reflected by lung pathological examination,TGF-β1 expression and hydroxyproline content were lighter in the drug therapy groups than those in the model group.Conclusion: YQHX decoction has a certain treating effect on the pulmonary fibrosis induced by bleomycin in rats,possibly through inhibition of TGF-β1 expression.

Key concepts: Bleomycin, Hydroxyproline, Decoction, Pulmonary fibrosis, Medicine, Lung, Prednisone, Pathological

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