Changes of Hematoxin,Lipopolysaccharide,Lipopolysaccharide Binding Protein/Membrane CD_(14) in Children with Systemic Inflammatory Response Syndrome

Objective To investigate the effect of hematoxin,lipopolysaccharide(LPS),lipopolysaccharide binding protein(LBP)/membrane CD14(mCD14) in occurrence and development of systemic inflammatory response syndrome(SIRS) in children.Methods Serum LPS,LBP,mean fluorescence intensity(MFI) of mCD14 on monocytes of 30 patients with SIRS were measured,at the same time 21 healthy children had been chosen to serve as control group.Results Compared with control group,the serum LPS,LBP,MFI of mCD14 on monocytes of patients with SIRS were significantly higher(Pa0.001).And with the increasing of serum LPS concentration,LBP/mCD14 increased,the two show marked positive correlation(r=0.710 P0.001).Conclusion LPS,LBP/mCD14 play an important role in the pathophysiological process of SIRS.LPS can increase LBP/mCD14 expression,and the expression of LBP/mCD14 increase is a machnism for LPS function.