Effect of Acupuncture on Contents of Leptin,Insulin and Neuropeptide Y in Obese Rats

Objective:It is to explore the effect of acupuncture on the contents and blood brain transport of leptin,insulin (INS) and neuropeptide Y (NPY) in obese organism.Methods:The changes of body weight,lee's index,body fat,levels of central and peripheral leptin,INS and NPY in obese rats were observed before and after acupuncture.Results:The body weight,lee's index,body fat,the contents of blood leptin,INS and NPY as well as hypothalamic NPY in the obese rats were all markedly higher than those in the normal rats,but the contents of hypothalamic Leptin and INS in obese rats were all lower than of normal rats.After acupuncture treatment the marked weight lose effect was achieved while the contents of blood leptin.INS and NPY as well as hypothalamic NPY obviously decreased,the contents of hypothalamic leptin and INS obviously increased in obese rats.Conclusion:The abnormal tramsport of blood brain barrier of leptin,INS and NPY may be an important reason for the obesity.The good regulation of acupuncture on levels of central and peripheral leptin,INS and NPY possibly were one of mechanism in the antiobesity action of acupuncture.