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Study on Growth Effect and Apoptosis Action of Quercetin on Human Gastric Carcinoma Cells MGC-803

Liya He

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Abstract

OBJECTIVE:To study the effect of quercetin on the proliferation and apoptosis of human gastric carcinoma cell line MGC-803.METHODS:MTT assay was adopted to measure the effect of quercetin at different concentrations on the proliferation of MGC-803 cells.Cell apoptosis index(AI)induced by quercetin was measured by TUNEL assay.RESULTS: Quercetin at a certain concentration from 40μmol/L to 100μmol/L could successfully inhibit the proliferation of MGC-803 cells in a dose-dependent manner.TUNEL assay indicated that apoptosis cells induced by quercetin in treatment group were much more than that in control group after 48 hours(P0.05).CONCLUSIONS:Quercetin of certain concentration can evidently inhibit the proliferation of MGC-803 cells and induce their apoptosis with concentration-dependent relation.

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OBJECTIVE:To study the effect of quercetin on the proliferation and apoptosis of human gastric carcinoma cell line MGC-803.METHODS:MTT assay was adopted to measure the effect of quercetin at different concentrations on the proliferation of MGC-803 cells.Cell apoptosis index(AI)induced by quercetin was measured by TUNEL assay.RESULTS: Quercetin at a certain concentration from 40μmol/L to 100μmol/L could successfully inhibit the proliferation of MGC-803 cells in a dose-dependent manner.TUNEL assay indicated that apoptosis cells induced by quercetin in treatment group were much more than that in control group after 48 hours(P0.05).CONCLUSIONS:Quercetin of certain concentration can evidently inhibit the proliferation of MGC-803 cells and induce their apoptosis with concentration-dependent relation.

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Available abstract

OBJECTIVE:To study the effect of quercetin on the proliferation and apoptosis of human gastric carcinoma cell line MGC-803.METHODS:MTT assay was adopted to measure the effect of quercetin at different concentrations on the proliferation of MGC-803 cells.Cell apoptosis index(AI)induced by quercetin was measured by TUNEL assay.RESULTS: Quercetin at a certain concentration from 40μmol/L to 100μmol/L could successfully inhibit the proliferation of MGC-803 cells in a dose-dependent manner.TUNEL assay indicated that apoptosis cells induced by quercetin in treatment group were much more than that in control group after 48 hours(P0.05).CONCLUSIONS:Quercetin of certain concentration can evidently inhibit the proliferation of MGC-803 cells and induce their apoptosis with concentration-dependent relation.

Key concepts: Quercetin, Apoptosis, TUNEL assay, Cell growth, Chemistry, MTT assay, Cell, Cell culture

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Study on Growth Effect and Apoptosis Action of Quercetin on Human Gastric Carcinoma Cells MGC-803 — Research Paper | ScholarLens