Progress in the pharmacodynamics of Repaglinide

Repaglinide is a short-acting,oral,insulin secretagogue used for the treatment of type 2 diabetes mellitus.The inter-individual differences of Repaglinide pharmacodynamics are not only correlation with the degree of impaired β-cell function and insulin resistance,but also correlation with the genetic polymorphism of the patients.The mecha nism of pharmacodynamic differences and its influence factors of Repaglinide have been reviewed in this paper,hope to understand its mechanism of action,in order to provide the basis for clinical medication,reduce the incidence of adverse reactions and promote the rational use of clinical drugs.