Subsequent treatment on low fertilization rate and fertilization failure in conventional IVF-ET cycles and analysis on clinical outcome

Objective: To explore the subsequent treatment on low fertilization rate and fertilization failure in conventional in vitro fertilization and embryo transfer( IVF-ET) cycles and analyze the clinical outcome. Methods: A total of 556 patients receiving IVF assisted reproductive technique were analyzed retrospectively,including 126 patients receiving early rescue intracytoplasmic sperm injection( R-ICSI) because of low fertilization rate or fertilization failure( group A),33 patients receiving rescue ICSI on the next morning( group B),and 397 patients receiving ICSI directly( group C); the normal fertilization rates,abnormal fertilization rates,cleavage rates,high-quality embryo rates,clinical pregnancy rates,embryo implantation rates,and abortion rates in the three groups were compared. Results: There was no statistically significant difference in normal fertilization rate,cleavage rate,high-quality embryo rate,clinical pregnancy rate,embryo implantation rate,and abortion rate between group A and group C( P 0. 05); the normal fertilization rate,high-quality embryo rate,clinical pregnancy rate,and embryo implantation rate in group A were statistically significantly higher than those in group B( P 0. 05).Conclusion: Short-period fertilization combined with early R-ICSI can find and rescue fertilization failure timely to improve embryonic potential and achieve good clinical outcome.