2005•Zhōnghuá yàoxué zázhìRequires access

Preparation of garlic oil submicron emulsion for intravenous administration

Ming Yan

Abstract

OBJECTIVE To prepare garlic oil submicron emulsion for intravenous administration. METHODS The garlic oil submicron emulsion was obtained after passing the elementary emulsion through a high pressure homogenizer. The physical and chemical stability of emulsions were evaluated with the stability parameters of centrifugation, content of garlicin and appearance of emulsion. The optimized formulation was established by orthogonal experimental design, and processing factors were studied based on the optimized formulation. RESULTS The garlic oil submicron emulsion with good and stable quality was prepared by controlling various processing factors. The intensity-weighted particle size distribution of garlic oil submicron emulsion was( 150.4 ?14.6)nm. CONCLUSION The garlic oil submicron emulsion made by this optimum formulation and preparative technique was fitted to be used for intravenous administration.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Homogenizer, Emulsion, Chromatography, Materials science, Particle size, Chemistry, Chemical engineering, Organic chemistry