Survey of 4 682 Female Cervical Human Papilloma Virus Infection and The Distribution of Genotype in Northeast of Yunnan

Objective To investigate the infectious situation of human papilloma virus in female cervix and provide an evidence for prevention and therapy of cervical carcinoma. Methods 4682 cases of specimens of cervical exfoliated epithelial cells from female cervix during 2012.05-2014.08 were collected. HPV infection was identified by the genotype features.The infectious situation of HPV,the distribution of its subtypes and the susceptible age to HPV infection were analyzed based on the genotype features. Results The total prevalence of infection was 13.86%(649/4682),and the high-risk HPV infection rate was 15.4%(721/4682). In 649 positive specimens,a total of853 strains of HPV subtypes(including multiple infection of double counting) were detected. The top three subtypes of the High-risk HPV were HPV16(16.41%,140/853),HPV52(14.65%,125/853) and HPV58(10.55%,90/853). On the other hand, the low-risk HPV infection rate was 2.82%(132/4682),of which the top three subtypes were HPV6(4.24%,37/853),HPV43(3.99%,34/853) and HPV11(3.52%,30/853). HPV infection rate showed a trend of decrease with the growth of age. In patients 24 years or younger, HPV infection rate was 21.52%. The difference in infectious rate between groups was statistically significant(P 0.05). Conclusion There is an obvious characteristic in age distribution for HPV infection in Zhaotong, Yunnan province.